Medicine Chest; Medicine Chest #22; #22 Merck

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just the names mike smith announcing research against modern research for when i was like some the research all right no exactly wilderness loans not skilled and one of them introduced to bring production facility student research laboratories that is to say to make compound somewhere like they've never been made before we've traditionally handcrafted compounds of your time with the rise of cheap automation sheep farmer a processor power we're now able to make robot facilities which are a large number of compounds automatically its worst option here this test pilot on an august ultimately sold for making huge numbers and there are a lot there is

our mission was recently in the market which is capable of doing what much of what's in the organic chemist posner we looked at a lot of bog along terrace automation fact joined consorting with the british insurance company and the six other pharmaceutical houses making synthesizer which we've implemented here were synthesizers capable of doing a hundred ninety two reactions simultaneously i think on a good day chemists would be hard pressed to do more than say three for a reaction simultaneously so this represents an enormous increase and were able to chase them leaves for more rapidly were able to do things that we wouldn't have done before if you can only make say fatah compounds and there are twenty five pounds a week you're not going to be as liberal and selecting the sorts of models are going to gather with automated services we can readily made huge numbers of compounds don't speculate morgan had things that you might not have touched before and all hoping that maybe haven't

chased them so long more traditional is strong in various therapeutic areas the my test as production facility to make a factory just capable of producing tens of thousands of their own pounds per year of protest and sought therapy and from here things go to two places and put them into small place that delivered directly involves ferocity those results until that fact tends to source of the compounds been married almost plays into our sample collection one of the nice things about saving thousand election was that that's when the lights come from it a lot of therapeutic there's more to discover that leads or compounds in different targets in order to do

that i think we do have to we do have through the screening here in which a huge numbers suggested announces the results reported that there are some houses which are capable of testing every compound on our collection which is a huge number within a matter of days with and take those results go back look at the structures most people more leads for new programs and just silence in the crowd and people who are the first you were a kid

cows build a month long whirl was just so since they're now session marking molecules off would be more secure foley's fun to just say i'm going to pass and still worries that years ago first learned that there was actually no mention whatsoever of insulin work and this is a fairly small wrong with papa was in chemistry a lot of elements of the songs are now so you'll have six trombones won't comment on the automated services are each awkwardness on her own parents

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my name is raja perlmutter and executive vice president for worldwide basic research and work well marcus so here we are her research laboratories at rahway were in the leave hundred which is our newest list of chemistry building the building is extraordinary for me and perspectives and i think exemplifies what's special about work the mission of course of our company is to discover developed manufacture and market breakthrough pharmaceutical address critical unmet medical needs and to do that we need to field a team of extremely

talented researchers who use an extraordinary array of technologies to define new molecules that will have beneficial effect here in this building now we have primarily buddhist the chemists and people involved in discovering how to actually synthesized materials and quantity that may be potentially useful to do that very use an array of instruments of extraordinary capabilities and we have to build a special building just to house the very large number of analytical instruments that are used to characterize new chemical compounds and we discover that we try to go well we have more and more automated instrumentation assisi of force throughout the world not just in the five seventh street many of the tasks that are involved

in trying to develop trying to discover drugs are fairly routine compounds are synthesized the actual synthesis steps involve moving solutions from one tune to another from one pile to another those compounds that need to be purified only be tested in a variety of biochemical setting though its old school then you know where we are now in the poor then yeah well

as i say we have one fundamental go everyone at merck is here because we want to discover develop manufacture and market breakthrough pharmaceutical compounds that will make a real difference to human beings we're here because we want to discover drugs and wondering what's for the drug discovery process is unbelievably arduous it's not enough to do great research everyone we have here on the research side has had the experience of training a great research laboratory has done great research themselves with the business of discovering a drug is so much harder than inevitably we find that after years of work and bringing forward a compound one of thousands of compounds and synthesized and tested for its biological fact we finally settle on one that seems to have

ideal properties only have our hopes dashed as we studied further and examine its properties in humans it's just an unbelievably difficult problem to approach but what we've learned over time is that the only way to be successful and discovery breakthrough pharmaceuticals is to apply the power of world class medicinal chemistry to the chemical problems and to synthesize thousands of compounds and to characterize the beauty in this building building eight hundred we have the largest cancer resource more research laboratories which is the largest medicinal chemistry town pool in the world and one c organization here in new jersey a week use the resources for a prison here to synthesize tens of thousands hundreds of thousands of compounds

that could be used ultimately as a platform to develop important drugs well there's absolutely no question that the identification of all of the genes in the human genome will have a powerful effect on biomedical research it already is having a powerful i think it's fair to say that represents a real sea change in the research environment because it means that you can simultaneously study all of the genes and their patterns of expression and their changes and expression in response to diseases in response to the administration of drugs and responses to changes in the environment exactly how we interpret those changes now use that to develop new drugs i think is more problematic while it's fair to say that knowing all the genes we know all of the potential drug targets at the same time it's also

fair to say that we don't really know how to use those drug targets we don't know which ones of them are really sort of the exercise that we go through here at merkin that everyone is going for around the world is trying to pick through this genetic information to identify those genes that encode proteins ever present real targets for pharmacological intervention and that sent an exercise that's going to take many decades and it's the idea of pleasure be in introducing fifteen drugs in five years that's an extraordinary record by any measure know at a pharmaceutical company no other organization never succeeded

in such a thing included within that group of fifteen drugs are some very important new therapies i guess i would highlight too one of those is singular bridges are you could try and before antagonists for asthma an extremely important oral wanted a compound that has very beneficial effects in asthmatic another drug which is suspension important and which has been much discussed his plots which is a highly selective non steroid all anti inflammatory drug of a new class of this compound this what's known as the cox two inhibitor and unlike previous drugs this compound selectively gets just one form of the cyclops in a sense i'm cox and was caught two and not cox one in this way it provides all of the analgesic potency that we associate with nods for lent

inflammatory drugs but it doesn't impose the same risk of gastrointestinal bleeding that's a very important new advance and we're stringing proud of that achievement it was an enormous investment for a moral scientists discovered was we brought it forward more rapidly than any compound that we previously been able to develop and it is extremely potent very safe wanted a compound he really the hallmark of both merck pharmaceuticals we always strive to identify compounds that are once a day taken a very low doses and very very se bikes has been extremely well accepted in the marketplace and we're very proud that we have a lot of exciting things in the pipeline within the next several months we will have the opportunity to to file we hope to

new antibiotic compounds one of those is a nine nine one insider's in this is a new antifungal agent which is really the first new approach to serious systemic fungal infections so for many many years we are very pleased with the compound it can be used in life threatening infections which previously had to be treated with drugs themselves have very significant toxic side effects and we also have another new antibiotic and kate to six which can be use so for bacterial infections that are resistant to many other kinds of antibiotics in which wall we think fine abroad use primarily in our hospital setting but will be an important new contribution to to read about it that they're so two compounds that were coming along with the right way we also have another new compound and pay six six three which were bringing forward as a second non story lent inflammatory

drug of the cox two inhibitor class that one were also very excited about so some really interesting new things are coming along and look very promising twenty minutes of ice is going summers when it's ninety nine percent what should i do i guess i would say i think there are two really important frontiers in terms of unmet medical need the problem of nerdy generation and we speak generally about alzheimer's disease but more generally the degenerative diseases is an extremely important one to address we've reached a point in human history where for the first time because of new drugs like those introduced by merck

life expectancy is actually increasing in the later years and as a result we're going to have an older population and the impact of degenerative disease particularly merger disease will become more profound it's something that we're working on very very assiduously mr but it's an enormous challenge in the near term i think better therapies for cancer are beginning to emerge and that reflects the impact of genetic analysis and of course the genomic programs that we talked about earlier yeah on our understanding of cancer as a disease process set new targets are merging in cancer biology and better therapies armored think those two fronts here's the latter somewhat in the near term the un and former pow are the major programs which would then have a significant impact over the next few decades eating think everyone

sees new jersey is the world's medicine chest years ago and someone said to me that you know work in the pharmaceutical industry should be aired live in jersey and and i think that's right and what has happened for many many rings visit the pharmaceutical industry's become concentration years and there is a unique resorts of talented people who train here grow up here who are interested in committing their lives to pharmaceutical discovery development and that helps to strengthen the industry overall we have an extremely good relationship with the state of new jersey and see it as an ideal place for discovering involving that's right thank you he's been fb